The coating is designed to reduce stable microbial attachment and biofilm formation across a broad range of microorganisms, including Gram-positive and Gram-negative bacteria as well as fungi, under defined test conditions. This effect is achieved without the use of antimicrobial agents, supporting a non-biocidal mode of action.

LubriShield® works through a non-biocidal surface engineering approach that prevents microorganisms from transitioning into biofilm-forming states. The coating creates a hydrated, dynamic surface environment that disrupts stable attachment, microbial surface sensing, and the molecular signalling processes required for biofilm development. As a result, microorganisms may remain present on the surface, but without forming structured biofilms.

Figure text: Proposed mechanism of action of the LubriShield® coating.
The coating combines three complementary surface-engineering mechanisms that interfere with biofilm development: (1) a hydrated surface barrier that limits stable attachment, (2) a dynamic ionic and water interface that disrupts microbial sensing and signalling, and (3) surface ligands that interfere with molecular recognition processes required for biofilm activation. Together, these mechanisms maintain microorganisms in a dispersed, non-biofilm state.

In addition to its surface properties, the coating provides low friction characteristics, contributing to comfort during the placement, use, and removal of devices such as urinary catheters and wound dressings.

The coating has been evaluated in a range of biocompatibility tests, including cytotoxicity, skin irritation, and implantation studies, demonstrating compatibility with biological tissues in accordance with relevant standards.